Although there was no significant intervention impact for the change in overall reported physical activity , whereas the control group had no significant modification.3 hours each day, P=0.3 hours each day, P=0.04). Neither the switch in television viewing nor the modification in any covariate apart from glucose intake mediated the intervention influence on the modification in BMI at 1 year. Ramifications of Ethnic Group In prespecified tests of covariates for interaction with group assignment, we found significant effect modification according to ethnic group for shifts in BMI and bodyweight .79, P=0.35, P=0.4 kg, P=0.8 kg, P=0.005) .Dr. Cuervo and her team found that the defective huntingtin proteins adhere to the inner layer of autophagosomes, stopping them from gathering garbage. The effect: Autophagosomes arrive empty at the lysosomes; and cellular components that should be recycled instead accumulate, causing toxicity that contributes to cell death. This acquiring, Dr. Cuervo noted, shows that activating the lysosomes of cells – among the proposed treatments for Huntington’s disease – won’t do worthwhile. It doesn’t matter how active your lysosomes are if they are not going to receive any cellular parts to digest, she stated. Instead, we have to concentrate on treatments to help autophagosomes recognize intracellular garbage, by minimizing their contact with the defective huntingtin protein perhaps.