Lorenzo Menicanti.

The Surgical Treatment for Ischemic Heart Failure trial was made to define the role of cardiac medical procedures in the treatment of patients with heart failure and coronary artery disease.15,16 One of the two key hypotheses of this trial was that surgical ventricular reconstruction, when added to CABG, would reduce the rate of hospitalization or death for a cardiac event, as compared with CABG alone. Methods Study Design We conducted a multicenter, nonblinded, randomized trial in 127 clinical sites in 26 countries.15 The trial was sponsored by the National Heart, Lung, and Blood Institute of the National Institutes of Health.As indicated in recent reports,5,6 we found that the MYD88 mutation was always associated with mutations in the IGHV area , which implies a postgerminal-middle origin. SF3B1 Mutations In the 192 leukemic samples in the discovery and extension sets, mutations in NOTCH1 were associated with unmutated IGHV status and mutations in MYD88 were associated with mutated IGHV status.048), nonetheless it was detected in samples with mutated IGHV also, which suggests that it’s an independent risk factor for chronic lymphocytic leukemia .