In this process, each end stage in the hierarchy was considered to be significant only if the P worth for that end stage and all prior end points indicated statistical significance. The hierarchical testing order and information on the test procedure are provided in the Supplementary Appendix. Additional end points not included in the hierarchical testing procedure were considered to be exploratory. Categorical variables were weighed against the usage of Fisher’s precise test or the chi-square test, as appropriate. All statistical analyses were performed with the use of SAS software, version 9.2 . Results Individuals From February 2011 through September 2012, a total of 995 individuals were screened for trial participation at 45 centers in the usa; of these individuals, 795 underwent randomized treatment assignment .Adolescent overweight and obesity may increase threat of all-cause ESRD Carrying excess fat and obese during adolescence shows up related to an increased threat of all-cause treated end-stage renal disease throughout a 25-12 months period, regarding to a report published Online Initial by Archives of Internal Medicine, a JAMA Network publication. Children and adolescents with high body mass index frequently become obese adults, and obese adults are in risk for chronic conditions such as diabetes, that may mean future risk of chronic kidney disease and ESRD, according to the scholarly study background.