There is currently no cure for HS and there are no approved medications for the treating the disease. The clinical signals of HS include nodules or abscesses. These can cause severe pain and foul-smelling discharge that can be upsetting for individuals, stated Alexa Kimball, M.D., M.P.H., PIONEER I Study Investigator, Medical Director at Massachusetts General Physicians Company and Professor of Dermatology at Harvard Medical School. Results of this study expand on earlier work demonstrating that adalimumab can decrease the nodules and abscesses in patients with moderate-to-severe HS.Many limitations of the scholarly study deserve mention. The combined statistical proof supporting a protective association with cardiovascular system disease is significant for a check of a single hypothesis but falls short of the exomewide significance threshold that might be used to account for multiple hypothesis screening across all genes (P=1.35 This stringent threshold can be used to limit false positive results of genetic association research35 involving many hypotheses, in which the prior probability of a genuine association is low.